CRYO-EM BASED 3D STRUCTURES THAT ENABLE YOUR DRUG DISCOVERY.
LARGE & CHALLENGING COMPLEXES.
High-resolution 3D Structures of full biochemical assemblies.
Leverage our cryo-EM services to gain essential insights into the full structure of your target - instead of focusing on incomplete structural data from isolated domains only.
Insights into the most challenging targets.
Now tackle targets that are hard to crystalize, like large assemblies or membrane proteins.
Our experience, your success.
Profit from our outstanding track record in handling macromolecular complexes and fragile assemblies. We have the experience and technological expertise to successfully solve
3D structures of your most challenging targets.
See the full picture of large & challenging targets.
High-resolution 3D atomic models of your ligands bound to the most challenging targets
No matter whether bound in a buried binding pocket, at the interface of two domains or even separate proteins of a larger complex – utilize our cryo-EM capabilities to rationalize your hit- or lead compound development by precise and high-resolution 3D atomic models.
One target – multiple ligands
Profit from our platform capabilities and let us screen multiple of your ligands on the same target. Our gains in efficiency allow us to offer you the best value for larger screening campaigns. Talk to one of our experts for more details on what we can do for you today.
Functional dynamics insights
Probe the impact on target dynamics during the binding of your small molecule compound(s) and obtain unprecedented functional insights on how your most promising lead candidates mechanistically interfere with your target
BIOLOGIC DRUGS.
Get new perspectives on protein-protein interactions with biological compounds.
3D structures of biologicals binding to their target complex
ATEM’s cryo-EM technology now enables the routine structure determination of
high-affinity protein-protein interactions -
in particular for monoclonal antibodies (mAbs, Fabs) or peptides.
Functional dynamics insights
Probe the impact on target dynamics during the binding of your biological compound(s) and obtain unprecedented functional insights on how your drug candidates mechanistically interfere with your target complex.
The new gold standard in efficient and precise 3D epitope mapping
No matter whether required for patent applications or rational drug design – we create high-resolution and unambiguous epitope maps that feature your target complexes in conjunction with a palette of mAb/Fab candidates.
FUNCTIONAL DYNAMIC MODELS.
For the first time, see your target at work with our cryo-EM based 3D dynamic structural models.
Protein complexes are naturally dynamic –
ATEM deciphers this motion with uniquely empirical 3D dynamic structural models
In contrast to being forced into a rigid crystal lattice, cryo-EM samples are flash-frozen in a myriad of structurally different, naturally occurring states. With ATEM’s increasingly efficient data recording- and processing platform we are now able to deliver more and more distinct dynamic states of a protein target at increasingly high resolution.
Leverage empirically determined, dynamic 3D structural data in your Medical Chemistry campaigns
Computationally selecting lead candidates against only one static structural state of your target may be unsuccessful. Focus your computational screening campaigns on multiple empirically determined, dynamic structural states of your target protein in order to maximise hit-rates an reduce attrition.
Hit / Lead selection & optimization
Gain high-resolution insights into how your most promising lead candidates (small molecule or biological) actually interfere with the biochemical mechanics of your target. Interprete distinct changes in empirically observable, dynamic profiles of your target complexes upon binding of a ligand to characterize, probe and optimize your drug candidates.
Ask our experts for more and tailored informations.
